04 D: Carbapenem Resistant Enterobacteriaceae
Lab Area: Microbiology
- This course includes types of infections from which CRE are isolated, the typical susceptibility profile for CRE, the role of hospital personnel when CRE is isolated from an inpatient, treatment options for CRE infections, and characteristics of 3 classes of enzymes and their respective carbapenemase.
Article used: “Carbapenem-Resistant Enterobacteriaceae – A Review for Laboratorians”, by Maria Navas, MD and Michael Jacobs, MD, PhD, in CLN, (8 pages)
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11 F: Role of ADAMTS13 Testing
Lab Area: Serology
- This course includes the effects of an ADAMTS13 deficiency, other diseases having the same symptoms as Thrombotic Thrombocytopenic Purpura (TTP), properties of ADAMTS13, attributes of ADAMTS13 activity assays, the differences between the ELISA and ADAMTS13 assays, attributes of the Bethesda assay, and the steps in the ADAMTS13 testing algorithm.
Article used: “The Role of ADAMTS13 Testing in the Workup of Suspected Thrombotic Thrombocytopenic Purpura”, by Kristi J. Smock, MD., in CLN, (7 pages).
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13 D: Hemoglobinopathies & Thalassemias
Lab Area: Hematology
- This course includes the differences between hemoglobinopathies and thalassemias regarding globulin chains, the attributes of alkaline gel electrophoresis in the area of hemoglobin variant identification, the analyses that can accurately quantitate Hb A2, the traits of beta and alpha thalassemias, and the information required to make informed judgments when interpreting hemoglobin analyses.
Article used: “Hemoglobinopathies and Thalassemias - Essentials for Clinical Consultation and Interpretation”, by Neil Harris, MD. and William Winter, MD., inCLN, (8 pages).
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28 F: Cell-Free DNA: Beyond Prenatal Testing
Lab Area: Molecular Pathology (ASCP's Molecular Biology)
- This course includes characteristics of circulating tumor-specific DNA analysis (ctDNA) for cancer management, advantages of ctDNA analysis of specific body fluids for management of certain medical conditions, and cfDNA in transplantation medicine.
Article used: “Cell-Free DNA: Beyond Prenatal Testing”, by Florent Mouliere, PhD, and Dana WY Tsui, PhD, in CLN, (6 pages).
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33 D: Beyond HbA1c
Lab Area: Chemistry
- This course includes the characteristics of HbA1c; factors that can affect the test results for HbA1c; intermediate indicators of glycemic control; pathologic conditions with which both HbA1c and GA were strongly associated; impacts of hemoglobin concentration, the erythropoietin dose, and serum albumin on both HbA1c results and GA levels; the contrasting HbA1c results and GA levels in a study of patients with advanced CKD; and interferences on GSP/GA that may result in a higher GA.
Article used: “Beyond HbA1c: Assessing the Utility of Fructosamine and Glycated Albumin Measurement”, by Randie R. Little, PhD, in CLN, (8 pages).
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34 F: RBC Alloimmunization In Sickle Cell Patients
Lab Area: Immunohematology (ASCPs Blood Banking)
- This course includes contributing factors suggested for a higher rate of alloimmunization in SCD transfused patients, the most common antibody found in the study subjects, the percentage of RBC antibodies against the Rh system found, and the practice that has become the standard of care in several institutions for reducing the risk of alloimmunization.
Article used: “Lifetime risk and characterization of red blood cell alloimmunization in chronically transfused patients with sickle cell disease", by Woldie I. et al., in IJBTI (International Journal of Blood Transfusion and Immunohematology), (9 pages).